| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Alkaloid-rich fraction of Himatanthus lancifolius contains anti-tumor agents against leukemic cells
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| Autores: |
Lima,Melissa Pires de
Hilst,Luciana Farhat
Mattana,Fernanda Vanessa Rechinbach
Santos,Cid Aimbiré de Moraes
Weffort-Santos,Almeriane Maria
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Apocynaceae
Cell proliferation
Himatanthus lancifolius
Indole alkaloids
Leukemia
Plant extract
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| Resumo: |
The effects of the alkaloid-rich fraction of Himatanthus lancifolius (Müll. Arg) Woodson on normal marrow cells and leukemic cell lines were investigated. After 48 h exposure, the proliferation assay showed significant cell growth inhibition for Daudi (0.1-10 µg/mL), K-562 (1-10 µg/mL), and REH cells (10-100 µg/mL), yet was inert for normal marrow cells. A similar inhibition profile was observed in clonogenic assays. This alkaloid-rich fraction, in which uleine is the main compound, showed no signs of toxicity to any cells up to 10 µg/mL. Cell feature analyses after induction of differentiation showed maintenance of the initial phenotype. Flow cytometric expression of Annexin-V and 7-AAD in K-562 and Daudi cells has indicated that the cells were not undergoing apoptosis or necrosis, suggesting cytostatic activity for tumor cells
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200014
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502010000200014
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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